pI: 8.6663 |
Length (AA): 394 |
MW (Da): 42548 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 10
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
32 | 337 | 1u7g (A) | 10 | 304 | 11.00 | 0.0000012 | 0.02 | 0.96 | -1.29 |
61 | 333 | 5i20 (B) | 32 | 282 | 16.00 | 0 | 0.61 | 0.708493 | 0.54 |
154 | 327 | 1orq (C) | 57 | 219 | 29.00 | 0.39 | 0.1 | 0.290324 | 1.76 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Oocyst. | Fritz HM |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_127989)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G35335 | Nucleotide-sugar transporter family protein |
Brugia malayi | Bm1_40725 | UDP-galactose transporter family protein |
Brugia malayi | Bm1_36330 | UDP-galactose transporter family protein |
Caenorhabditis elegans | CELE_ZK896.9 | Protein NSTP-5, isoform B |
Caenorhabditis elegans | CELE_C03H5.2 | Protein NSTP-4 |
Caenorhabditis elegans | CELE_M02B1.1 | Protein SRF-3, isoform C |
Cryptosporidium hominis | Chro.20067 | nucleotide-sugar transporter (2A681) |
Cryptosporidium parvum | cgd2_590 | nucleotide-sugar transporter, UDP N-acetylglucosamine-like, signal peptide, 9 or more transmembrane domains |
Drosophila melanogaster | Dmel_CG2675 | CG2675 gene product from transcript CG2675-RC |
Echinococcus granulosus | EgrG_000885800 | nucleotide sugar transporter |
Echinococcus granulosus | EgrG_000513900 | UDP N acetylglucosamine transporter |
Entamoeba histolytica | EHI_050270 | UDP-N-acetylglucosamine transporter, putative |
Echinococcus multilocularis | EmuJ_000513900 | UDP N acetylglucosamine transporter |
Echinococcus multilocularis | EmuJ_000885800 | nucleotide sugar transporter |
Homo sapiens | ENSG00000102100 | solute carrier family 35 (UDP-galactose transporter), member A2 |
Homo sapiens | ENSG00000117620 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 |
Leishmania braziliensis | LbrM.18.0420 | UDP-galactose transporter |
Leishmania donovani | LdBPK_180400.1 | UDP-galactose transporter |
Leishmania infantum | LinJ.18.0400 | UDP-galactose transporter |
Leishmania major | LmjF.18.0400 | UDP-galactose transporter |
Leishmania mexicana | LmxM.18.0400 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_14455 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02557 | UDP-galactose transporter |
Loa Loa (eye worm) | LOAG_13056 | hypothetical protein |
Loa Loa (eye worm) | LOAG_09074 | UDP-galactose transporter |
Mus musculus | ENSMUSG00000027957 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3 |
Mus musculus | ENSMUSG00000031156 | solute carrier family 35 (UDP-galactose transporter), member A2 |
Neospora caninum | NCLIV_038800 | hypothetical protein |
Schistosoma japonicum | Sjp_0007790 | UDP-N-acetylglucosamine transporter, putative |
Schistosoma japonicum | Sjp_0085220 | UDP-N-acetylglucosamine transporter, putative |
Schistosoma mansoni | Smp_065770.2 | sugar transporter |
Schistosoma mansoni | Smp_008580 | sugar transporter |
Schistosoma mansoni | Smp_065770.1 | sugar transporter |
Schmidtea mediterranea | mk4.005919.00 | UDP-galactose translocator |
Schmidtea mediterranea | mk4.004310.01 | Putative sugar transporter |
Schmidtea mediterranea | mk4.000675.13 | UDP-galactose translocator |
Schmidtea mediterranea | mk4.003421.03 | Putative sugar transporter |
Trypanosoma brucei gambiense | Tbg972.10.17080 | UDP-galactose transporter, putative |
Trypanosoma brucei | Tb927.10.13900 | Nucleotide sugar transporter 1 |
Trypanosoma congolense | TcIL3000_10_11780 | UDP-galactose transporter |
Trypanosoma congolense | TcIL3000.11.16480 | CMP-sialic acid transporter, putative |
Trypanosoma cruzi | TcCLB.511277.400 | UDP-galactose transporter |
Toxoplasma gondii | TGME49_267380 | UDP-galactose transporter subfamily protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.13900 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.13900 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.13900 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.13900 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_267380 this record | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.